sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20240601sibmed-1830Research ArticleОБЗОРЫREVIEWSОсобенности течения постковидного астеновегетативного синдрома: обзор литературыDynamics of post-COVID asthenia: reviewhttps://orcid.org/0000-0001-5092-4744АгейкинА. В.AgeykinA. V.

Агейкин Алексей Викторович - к.м.н.

440026, Пенза, ул. Красная, 40

Alexey V. Ageykin - candidate of medical sciences.

440026, Penza, Krasnaya st., 40

AgeykinAV@yandex.ruhttps://orcid.org/0000-0001-5232-7337УсенкоД. В.UsenkoD. V.

Усенко Денис Валериевич - д.м.н.

111123, Москва, ул. Новогиреевская, 3а

Denis V. Usenko - doctor of medical sciences.

11123, Moscow, Novogireyevskaya st., 3a

dusenko@rambler.ruhttps://orcid.org/0000-0001-9257-0171ГореловА. В.GorelovA. V.

Горелов Александр Васильевич - д.м.н., проф., акад. РАН.

111123, Москва, ул. Новогиреевская, 3а; 1127006, Москва, ул. Долгоруковская, 4

Alexandr V. Gorelov - doctor of medical sciences, professor, academician of the RAS.

111123, Moscow, Novogireyevskaya st., 3a; 1127006, Moscow, Dolgorukovskaya st., 4

agorelov_05@mail.ruhttps://orcid.org/0000-0002-2175-5547МельниковВ. Л.MelnikovV. L.

Мельников Виктор Львович - д.м.н.

440026, Пенза, ул. Красная, 40

Victor L. Melnikov - doctor of medical sciences, professor.

440026, Penza, Krasnaya st., 40

meib@pnzgu.ruhttps://orcid.org/0000-0003-4308-9597АфтаеваЛ. Н.AftaevaL. N.

Афтаева Лариса Николаевна - к.м.н.

440026, Пенза, ул. Красная, 40

Larisa N. Aftaeva - candidate of medical sciences.

440026, Penza, Krasnaya st., 40

l.aftaeva@mail.ruhttps://orcid.org/0000-0002-9130-3255МилтыхИ. С.MiltykhI. S.

Милтых Илья Сергеевич.

440026, Пенза, ул. Красная, 40

Ilia S. Miltykh.

440026, Penza, Krasnaya st., 40

i.miltykh@pnzgu.ruhttps://orcid.org/0009-0003-5389-5100БотоваВ. С.BotovaV. S.

Ботова Валерия Сергеевна.

440026, Пенза, ул. Красная, 40

Valeria S. Botova.

440026, Penza, Krasnaya st., 40

valeriabotova00@mail.ruhttps://orcid.org/0009-0008-1886-9579КикичеваА. А.KikichevaA. A.

Кикичева Алина Альбертовна.

440026, Пенза, ул. Красная, 40

Alina A. Kikicheva.

440026, Penza, Krasnaya st., 40

kikicheva18@gmail.comhttps://orcid.org/0009-0000-5759-0484ЛопатинаВ. А.LopatinaV. A.

Лопатина Владлена Александровна.

440026, Пенза, ул. Красная, 40

Vladlena A. Lopatina.

440026, Penza, Krasnaya st., 40

lopatina.vladlena@mail.ruhttps://orcid.org/0009-0008-2008-1852ДолгачевМ. В.DolgachevM. V.

Долгачев Максим Витальевич.

440026, Пенза, ул. Красная, 40

Maxim V. Dolgachev.

440026, Penza, Krasnaya st., 40

dolgachev08@mail.ruПензенский государственный университетРоссияPenza State UniversityRussian FederationЦентральный НИИ эпидемиологии РоспотребнадзораРоссияCentral Research Institute of Epidemiology of RospotrebnadzorRussian FederationЦентральный НИИ эпидемиологии Роспотребнадзора; Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияCentral Research Institute of Epidemiology of Rospotrebnadzor; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202406012025446616Copyright © Агейкин А.В., Усенко Д.В., Горелов А.В., Мельников В.Л., Афтаева Л.Н., Милтых И.С., Ботова В.С., Кикичева А.А., Лопатина В.А., Долгачев М.В., 20252025Агейкин А.В., Усенко Д.В., Горелов А.В., Мельников В.Л., Афтаева Л.Н., Милтых И.С., Ботова В.С., Кикичева А.А., Лопатина В.А., Долгачев М.В.Ageykin A.V., Usenko D.V., Gorelov A.V., Melnikov V.L., Aftaeva L.N., Miltykh I.S., Botova V.S., Kikicheva A.A., Lopatina V.A., Dolgachev M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1830

Новая коронавирусная инфекция (COVID-19) – высококонтагиозное респираторное заболевание, вызываемое коронавирусом SARS-CoV-2. Для COVID-19 характерно действие как на дыхательную, так и на пищеварительную, выделительную и нервную системы. В настоящее время растет частота хронических последствий новой коронавирусной инфекции. Цель работы – рассмотреть эпидемиологию и компоненты постковидного астеновегетативного синдрома. Материал и методы. Материалом для исследования явились 63 посвященных SARS-CoV-2, MERS и COVID-19 литературных источника, которые были опубликованы с 2005 по 2023 г. и проиндексированы в базах данных PubMed, Киберленинка, РИНЦ, Semantic Scholar и Google Scholar. Результаты. В ходе проведенного исследования выявлено, что наиболее частыми симптомами астеновегетативного синдрома в период пост-COVID являются усталость, мышечная слабость, одышка, нарушения сна, тревога или депрессия, ухудшение памяти и когнитивных функций (ощущение «тумана» в голове), гипосмия, снижение работоспособности. Одним из специфических постковидных симптомокомплексов является астеновегетативный синдром, частота возникновения которого согласно данным метаанализа колеблется от 13,1 до 72,8 %, в совокупности – 45 ± 0,05 % (95%-й доверительный интервал 0,31–0,54). Заключение. В настоящее время вопрос о постковидном астеновегенативном синдроме стоит весьма остро. Для разработки адекватной стратегии борьбы с ним необходимо детально рассмотреть имеющиеся данные об эпидемиологии и симптомах.

Novel coronavirus infection (COVID-19) is a highly contagious respiratory disease caused by the SARS-CoV-2 coronavirus. COVID-19 is known to affect both the respiratory, digestive, excretory, and nervous systems. The incidence of chronic effects of the novel coronavirus infection is now on the rise. This paper is aimed to review the epidemiology, pathogenesis and components of post-COVID asthenia. Material and methods. Sixty-three references published between 2005 and 2023 and indexed in the PubMed, CyberLeninka, Russian Citation Index, Semantic Scholar, and Google Scholar databases were included in this review. Results. The study revealed the most common symptoms of post-COVID asthenia are fatigue, muscle weakness, shortness of breath, sleep disturbances, anxiety or depression, impaired memory and cognitive functions (“foggy brain”), hyposmia, and reduced work performance. One of the specific symptom complexes for post-COVID is asthenovegetative syndrome, the incidence of which according to the meta-analysis ranged from 13.1 to 72.8 %, with a cumulative percentage of 45 ± 0.05 % (95 % confidence interval 0.31–0.54). Conclusions. Nowadays, post-COVID asthenia is becoming extremely severe. It is necessary to review in detail the available data on the epidemiology and components of post-COVID asthenia in order to develop an adequate strategy for post-COVID management.

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The authors declare that there are no conflicts of interest present.