sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20240506sibmed-1702Research ArticleОБЗОРЫREVIEWSРоль внеклеточной АТФ в регуляции функциональной активности клетокThe role of extracellular ATP in regulating the functional activity of cellshttps://orcid.org/0000-0001-6219-5964ПатракееваВ. П.PatrakeevaV. P.

Патракеева Вероника Павловна, к.б.н.

163065, г. Архангельск, пр. Никольский, 20

Veronika P. Patrakeeva, candidate of biological sciences

163065 Arkhangelsk, Nikolsky ave., 20

patrakeewa.veronika@yandex.ruИнститут физиологии природных адаптаций ФИЦ комплексного изучения Арктики им. академика Н.П. Лаверова УроРАНРоссияInstitute of Physiology of Natural Adaptations of N. Laverov Federal Center for Integrated Arctic Research of UrB RASRussian Federation2024301020244455360Copyright © Патракеева В.П., 20242024Патракеева В.П.Patrakeeva V.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1702

Выполнены поиск и акализ научных статей, представленных в базах данных PubMed, ScienceDirect, Elsevier, eLibrary за 2000–2024 гг. Критерием отбора служило наличие в статьях информации о концентрации внеклеточной АТФ в нормальных и патологических тканях, механизмах пуринергической регуляции функционирования клеток, экспрессии на клетках эктонуклеотидаз CD73 и CD39, регулирующих катаболизм провоспалительной внеклеточной АТФ до иммуносупрессивного аденозина. Представлены современные данные о роли внеклеточной АТФ в регуляции функционирования клеток в норме и при патологии, при воспалении, формировании клеточного и гуморального иммунного ответа, а также об изучении механизмов пуринергической передачи сигналов от внеклеточной АТФ при разработке таргетных лекарственных препаратов при различных заболеваниях, включая новообразования, нейродегенеративные и аутоиммунные патологии.

A search and analysis of scientific articles presented in the databases PubMed, ScienceDirect, Elsevier, eLibrary for 2000–2024 was carried out. The selection criterion was the presence in the articles of information on the concentration of extracellular ATP in normal and pathological tissues, the mechanisms of purinergic regulation of cell functioning, and the expression of CD73 and CD39 ectonucleotidases on cells, which regulate proinflammatory extracellular ATP catabolism to immunosuppressive adenosine. Modern data are presented on the role of extracellular ATP in the regulation of cell functioning under normal and pathological conditions, during inflammation and the formation of cellular and humoral immune responses, as well as on the study of the mechanisms of purinergic signaling from extracellular ATP in the development of targeted drugs for various diseases, including neoplasms, neurodegenerative and autoimmune pathologies.

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The authors declare that there are no conflicts of interest present.