sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20240504sibmed-1700Research ArticleОБЗОРЫREVIEWSРоль эпителиальных аларминов и Th2-цитокинов в развитии воспалительной реакции при аллергическом ринитеThe role of epithelial alarmins and Th2 cytokines in the inflammatory response in allergic rhinitishttps://orcid.org/0009-0008-7623-8839МакаревичВ. В.MakarevichV. V.

Макаревич Василина Вадимовна

220083, г. Минск, пр. Дзержинского, 83

Vasilina V. Makarevich

220083, Minsk, Dzerzhinskogo ave., 83

vasilinamkrvch@gmail.comhttps://orcid.org/0000-0002-0668-2888ТагановичА. Д.TaganovichA. D.

Таганович Анатолий Дмитриевич, д.м.н., проф.

220083, г. Минск, пр. Дзержинского, 83

Anatoly D. Taganovich, doctor of medical sciences, professor

220083, Minsk, Dzerzhinskogo ave., 83

taganovich@bsmu.byhttps://orcid.org/0009-0008-9884-1639МироноваТ. В.MironovaT. V.

Миронова Татьяна Витальевна

220083, г. Минск, пр. Дзержинского, 83

Tatiana V. Mironova

220083, Minsk, Dzerzhinskogo ave., 83

tomanis@mail.ruhttps://orcid.org/0000-0001-5343-4230ШиловскийИ. П.ShilovskiyI. P.

Шиловский Игорь Петрович, д.б.н.

115522, г. Москва, Каширское шоссе, 24

Igor P. Shilovskiy, doctor of biological sciences

115522, Moscow, Kashirskoe highw., 24

ip.shilovsky@nrcii.ruhttps://orcid.org/0000-0003-4961-9640ХаитовМ. Р.KhaitovM. R.

Хаитов Муса Рахимович, д.м.н., проф., чл.-корр. РАН

115522, г. Москва, Каширское шоссе, 24 

117997, г. Москва, ул. Островитянова, 1

Musa R. Khaitov, doctor of medical sciences, professor, corresponding member of RAS

115522, Moscow, Kashirskoe highw., 24

117997, Moscow, Ostrovityanova st., 1

mr.khaitov@nrcii.ruhttps://orcid.org/0000-0002-1620-8477КадушкинА. Г.KadushkinA. G.

Кадушкин Алексей Геннадьевич, д.м.н.

220083, г. Минск, пр. Дзержинского, 83

Aliaksei G. Kadushkin, doctor of medical sciences

220083, Minsk, Dzerzhinskogo ave., 83

kadushkyn@gmail.comБелорусский государственный медицинский университет Минздрава Республики БеларусьБеларусьBelarusian State Medical University of Minzdrav of the Republic of BelarusBelarusГосударственный научный центр «Институт иммунологии» ФМБА РоссииРоссияNational Research Center – Institute of Immunology of the Federal Medical-Biological AgencyRussian FederationГосударственный научный центр «Институт иммунологии» ФМБА России ; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияNational Research Center – Institute of Immunology of the Federal Medical-Biological Agency ; N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationRussian Federation2024301020244453545Copyright © Макаревич В.В., Таганович А.Д., Миронова Т.В., Шиловский И.П., Хаитов М.Р., Кадушкин А.Г., 20242024Макаревич В.В., Таганович А.Д., Миронова Т.В., Шиловский И.П., Хаитов М.Р., Кадушкин А.Г.Makarevich V.V., Taganovich A.D., Mironova T.V., Shilovskiy I.P., Khaitov M.R., Kadushkin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1700

Аллергический ринит (АР) занимает лидирующие позиции среди причин заболеваемости во всем мире, на сегодняшний день он выявлен у 400 млн человек. В формировании и прогрессировании АР значимую роль отводят цитокинам, ассоциированным со вторым типом иммунного ответа, в частности, ИЛ-4, ИЛ-5, ИЛ-9, ИЛ-13, ИЛ-25, ИЛ-33, тимическому стромальному лимфопоэтину (ТСЛП). В настоящем обзоре литературы приведены сведения о влиянии перечисленных медиаторов на структурные клетки полости носа и иммунокомпетентные клетки крови (Т- и В-лимфоциты, эозинофилы, макрофаги, дендритные клетки), обсуждается их связь с проявлением симптомов, характерных для АР, и тяжестью течения заболевания. Оцениваются результаты исследований, направленных на установление уровня ИЛ-4, ИЛ-5, ИЛ-9, ИЛ-13, ИЛ-25, ИЛ-33 и ТСЛП в биологических жидкостях (сыворотке крови, смывах полости носа) и их экспрессии в эпителиальных клетках носа у пациентов с АР по сравнению со здоровыми людьми.

Allergic rhinitis (AR) occupies a leading position among the causes of morbidity throughout the world, to date, it has been diagnosed in 400 million people. In the formation and progression of AR, a significant role is assigned to cytokines associated with the second type of immune response, in particular, IL-4, IL-5, IL-9, IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP). This literature review provides information on the influence of the listed mediators on the structural cells of the nasal cavity and blood immune cells (T- and B-lymphocytes, eosinophils, macrophages, dendritic cells), and discusses their association with the manifestation of AR symptoms and the severity of the disease. The results of studies aimed at establishing the level of IL-4, IL-5, IL-9, IL-13, IL-25, IL-33 and TSLP in biological fluids (blood serum, nasal lavage) and their expression in nasal epithelial cells in patients with AR compared to healthy people are assessed.

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The authors declare that there are no conflicts of interest present.