sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20240302sibmed-1543Research ArticleОБЗОРЫREVIEWSАдаптогенные свойства манжетки обыкновенной (Alchemilla vulgaris L.) (обзор литературы)Adaptogenic properties of the Lady’s Mantle (Alchemilla vulgaris L.) (literature review)https://orcid.org/0000-0002-3093-0749ПальчиковаН. А.PalchikovaN. A.

Пальчикова Наталья Александровна, д.б.н.

630117, г. Новоcибирск, ул. Тимакова, 2

Natalya A. Palchikova, doctor of biological sciences

630117, Novosibirsk, Timakova st., 2

labend@mail.ruhttps://orcid.org/0000-0003-4534-7289СелятицкаяВ. Г.SelyatitskayaV. G.

Селятицкая Вера Георгиевна, д.б.н., проф.

630117, г. Новоcибирск, ул. Тимакова, 2

Vera G. Selyatitskaya, doctor of biological sciences, professor

630117, Novosibirsk, Timakova st., 2

vgSelyatitskaya@frcftm.ruhttps://orcid.org/0000-0001-9425-413XВоеводаМ. И.VoevodaM. I.

Воевода Михаил Иванович, д.м.н., проф., акад. РАН

630117, г. Новоcибирск, ул. Тимакова, 2

Mikhail I. Voevoda, doctor of medical sciences, professor, academician of the RAS

630117, Novosibirsk, Timakova st., 2

director@frcftm.ruФИЦ фундаментальной и трансляционной медициныРоссияFederal Research Center for Fundamental and Translational MedicineRussian Federation2024030720244431628Copyright © Пальчикова Н.А., Селятицкая В.Г., Воевода М.И., 20242024Пальчикова Н.А., Селятицкая В.Г., Воевода М.И.Palchikova N.A., Selyatitskaya V.G., Voevoda M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1543

Адаптогены представляют собой категорию растительных лекарственных продуктов, способствующих повышению адаптивных резервов организма, устойчивости к действию экстремальных факторов и выживанию в условиях стресса. Адаптогенные свойства выявлены у десятков растений, в частности, препараты на основе сырья из манжетки обыкновенной (Alchemilla vulgaris L.), многолетнего травянистого растения из семейства розоцветных, обладают широким спектром биологической активности, включая антиоксидантную, противовоспалительную, нейропротекторную, противораковую и др., что позволяет использовать их для профилактики и поддерживающей терапии при лечении многих патологических процессов. Результаты собственных исследований авторов и ряд данных литературы обосновывают наличие адаптогенных свойств у этого растения. В обзоре анализируются сведения научной литературы о химическом составе соединений, входящих в состав препаратов на основе сырья A. vulgaris, современная трактовка понятия «адаптоген» и критерии оценки адаптогенных свойств растений, а также обсуждаются возможные молекулярно-клеточные механизмы, обеспечивающие наличие таких свойств у манжетки обыкновенной.

Adaptogens are a category of herbal medicinal products that enhance the adaptive reserves of the body, resistance to extreme factors and survival under stress. Adaptogenic properties have been revealed in dozens of plants, in particular, preparations based on raw materials from the Lady’s Mantle (Alchemilla vulgaris L.), a perennial herbaceous plant from the family Rosaceae, have a wide range of biological activity, including antioxidant, antiinflammatory, neuroprotective, anticancer and other, which allows them to be used for prevention and supportive therapy in the treatment of many pathological processes. The results of the authors’ own research and a number of literature data substantiate the presence of adaptogenic properties in this plant. The review analyzes the information in the scientific literature on the chemical composition of compounds included in preparations based on A. vulgaris raw materials, the modern interpretation of the concept of “adaptogen” and criteria for evaluating the adaptogenic properties of plants, and discusses possible molecular and cellular mechanisms that ensure the presence of such properties in the Lady’s Mantle.

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The authors declare that there are no conflicts of interest present.