sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20240113sibmed-1396Research ArticleОБЗОРЫREVIEWSЦитокины при гриппе у детей (обзор литературы)Cytokines in influenza in children (literature review)https://orcid.org/0000-0003-0692-2295КазанцеваЕ. Д.KazantsevaE. D.

Казанцева Екатерина Дмитриевна 

664003, г. Иркутск, ул. Тимирязева, 16

Ekaterina D. Kazantseva 

664003, Irkutsk, Timiryazeva st., 16

kat.smile7@yandex.ruhttps://orcid.org/0000-0002-7965-8061ПетроваА. Г.PetrovaA. G.

Петрова Алла Германовна, д.м.н., проф. 

664003, г. Иркутск, ул. Тимирязева, 16

Alla G. Petrova, doctor of medical sciences, professor 

664003, Irkutsk, Timiryazeva st., 16

rudial75@gmail.comhttps://orcid.org/0000-0002-0117-2563РычковаЛ. В.RychkovaL. V.

Рычкова Любовь Владимировна, д.м.н., проф., чл.-корр. РАН 

664003, г. Иркутск, ул. Тимирязева, 16

Lyubov V. Rychkova, doctor of medical sciences, professor, corresponding member of the RAS 

664003, Irkutsk, Timiryazeva st., 16

iphr@sbamsr.irk.ruhttps://orcid.org/0000-0003-3255-2013ДаренскаяМ. А.DarenskayaM. A.

Даренская Марина Александровна, д.б.н., проф. РАН 

664003, г. Иркутск, ул. Тимирязева, 16

Marina A. Darenskaya, doctor of biological sciences, professor of the RAS 

664003, Irkutsk, Timiryazeva st., 16

marina_darenskaya@inbox.ruНаучный центр проблем здоровья семьи и репродукции человекаРоссияScientific Center for Family Health and Human Reproduction ProblemRussian Federation202407032024441124138Copyright © Казанцева Е.Д., Петрова А.Г., Рычкова Л.В., Даренская М.А., 20242024Казанцева Е.Д., Петрова А.Г., Рычкова Л.В., Даренская М.А.Kazantseva E.D., Petrova A.G., Rychkova L.V., Darenskaya M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1396

Данный обзор литературы был составлен по данным поисковых систем PubMed, eLIBRARY.RU, Google Scholar, поиск выполнен по ключевым словам «грипп», «цитокины», «дети» (influenza, cytokines, children). В статье освещены вопросы участия провоспалительных и противовоспалительных цитокинов в патогенезе гриппа, проведено сравнение цитокинового профиля при разных штаммах вируса, при сопутствующей патологии, а также сделана попытка найти ответ на вопрос: «Почему дети младшего возраста более подвержены этой инфекции?». Представлены сведения о создании экспресс-систем для диагностики цитокинового шторма у больных гриппом и другими острыми респираторными вирусными инфекциями с учетом комплекса клинических и лабораторных данных, которые приходят на помощь практикующему врачу. Следует отметить, что присутствуют разные мнения авторов в отношении ранних маркеров тяжелого и осложненного течения гриппа в детском возрасте. Это делает тему изучения значимости цитокинов при гриппе у детей актуальной, но нуждающейся в продолжении и уточнении знаний по данному вопросу.

This literature review was compiled according to the data of search engines PubMed, eLIBRARY.RU, Google Scholar using key words influenza, cytokines, children. The article highlights the participation of pro-inflammatory and antiinflammatory cytokines in the pathogenesis of influenza, compares the cytokine profile in different strains of the virus, with concomitant pathology, as well as attempts to find an answer to the question: “Why are young children more susceptible to this infection?” The article contains information about the creation of express systems for diagnosing cytokine storm in patients with influenza and other acute respiratory viral infections, taking into account a complex of clinical and laboratory data that comes to the aid of a practicing physician. It should be noted that there are different opinions among authors regarding the early markers of severe and complicated influenza in childhood. This information makes the topic of studying the significance of cytokines in influenza in children relevant, but it requires continuation and clarification of knowledge on this issue.

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The authors declare that there are no conflicts of interest present.