sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20230602sibmed-1302Research ArticleОБЗОРЫREVIEWSВзаимосвязь сосудистой кальцификации, остеопороза и системного воспаленияRelationship between vascular calcification, osteoporosis and systemic inflammationhttps://orcid.org/0009-0006-5638-9416НичипорукК. А.NichiporukK. A.

Ничипорук Ксения Александровна

672000, Чита, ул. Горького, 39а

Ksenia A. Nichiporuk

672000, Chita, Gorkogo st., 39a

ksenya.nichiporuk.98@mail.ruhttps://orcid.org/0000-0002-7065-5737ЦаренокС. Ю.TsarenokS. Yu.

Царенок Светлана Юрьевна - д.м.н.

672000, Чита, ул. Горького, 39а

Svetlana Yu. Tsarenok - doctor of medical sciences.

672000, Chita, Gorkogo st., 39a

sveta-tsarenok@yandex.ruhttps://orcid.org/0000-0001-7352-6618ГорбуновВ. В.GorbunovV. V.

Горбунов Владимир Владимирович - д.м.н., проф.

672000, Чита, ул. Горького, 39а

Vladimir V. Gorbunov - doctor of medical sciences, professor.

672000, Chita, Gorkogo st., 39a

gorbunvvv2008@mail.ruhttps://orcid.org/0000-0003-3960-631XИльямаковаН. А.IlyamakovaN. A.

Ильямакова Наталья Александровна - к.м.н.

672039, Чита, ул. Ленина, 4

Natalya A. Ilyamakova - candidate of medical sciences.

672039, Chita, Lenina st., 4

iljamakovy@yandex.ruhttps://orcid.org/0000-0003-4957-5908АксеноваТ. А.AksenovaT. A.

Аксенова Татьяна Александровна - д.м.н., проф.

672000, Чита, ул. Горького, 39а

Tatiana A. Aksenova - doctor of medical sciences, professor.

672000, Chita, Gorkogo st., 39a

tatianaks@mail.ruЧитинская государственная медицинская академия Минздрава РоссииРоссияChita State Medical Academy of Minzdrav of RussiaRussian FederationКлиническая больница «РЖД-Медицина» города ЧитаРоссияClinical Hospital “RR-Medicine” of ChitaRussian Federation2023100120244361423Copyright © Ничипорук К.А., Царенок С.Ю., Горбунов В.В., Ильямакова Н.А., Аксенова Т.А., 20242024Ничипорук К.А., Царенок С.Ю., Горбунов В.В., Ильямакова Н.А., Аксенова Т.А.Nichiporuk K.A., Tsarenok S.Y., Gorbunov V.V., Ilyamakova N.A., Aksenova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1302

Сосудистая кальцификация часто встречается у пациентов с коронарной болезнью сердца и сопровождается неблагоприятными кардиоваскулярными событиями. В обзоре литературы отражены современные представления о взаимосвязи остеопороза, сосудистого кальциноза и системного воспаления. Обсуждаются общие патогенетические механизмы снижения минеральной плотности кости и развития сосудистой кальцификации. Несмотря на растущее число исследований, касающихся сочетанной патологии сердечно-сосудистой и костной систем, в настоящее время пока не установлена причинно-следственная связь между сосудистой кальцификацией и снижением костной массы. Кроме этого на сегодняшний день в литературе недостаточно данных о влиянии системного воспаления на процессы кальцификации. В настоящем обзоре на основе анализа имеющихся клинических и экспериментальных исследований описаны главные патогенетические механизмы сосудистой кальцификации при коронарном атеросклерозе. Обсуждаются вопросы влияния препаратов кальция и витамина D на развитие сосудистой кальцификации, а также ранние и отдаленные последствия чрескожного коронарного вмешательства и коронарного шунтирования у пациентов с наличием сосудистого кальциноза.

A lot of patients with coronary heart disease often suffer from vascular calcification. In many cases it is accompanied by harmful cardiovascular events. The modern ideas of the relationship between osteoporosis, vascular calcification and inflammation, the general mechanisms of development of vascular calcification and low bone mineral density are discussed. Despite a growing number of studies concerning the combined pathology of the cardiovascular and skeletal systems, a causal relationship between vascular calcification and a decrease in bone mass has not yet been established. Moreover, there is insufficient data on the effect of inflammation on ectopic calcification. Based on the analysis of available clinical and experimental studies, this review describes the main pathogenetic mechanisms of vascular calcification in coronary atherosclerosis. The influence of calcium and vitamin D medicines on the development of vascular calcification is discussed in this article. The author’s attention is focused on early and long-term consequences of percutaneous coronary intervention and coronary bypass surgery in patients with vascular calcification.

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The authors declare that there are no conflicts of interest present.