sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20230503sibmed-1235Research ArticleОБЗОРЫREVIEWSБелок PRDM16 и его значение для жировой ткани (обзор литературы)Protein PRDM16 and its importance for adipose tissue (literature review)https://orcid.org/0000-0003-4726-3599АфанаскинаЛ. Н.AfanaskinaL. N.

к.б.н.

660022, г. Красноярск, ул. Партизана Железняка, 1

candidate of biological sciences

660022, Krasnoyarsk, Partizana Zheleznyaka st., 1

afanln@mail.ruhttps://orcid.org/0000-0003-2974-5930ДеревцоваС. Н.DerevtsovaS. N.

д.м.н.

660022, г. Красноярск, ул. Партизана Железняка, 1

doctor of medical sciences

660022, Krasnoyarsk, Partizana Zheleznyaka st., 1

Derevzova@bk.ruhttps://orcid.org/0000-0001-6905-980XЧекишеваТ. Н.ChekishevaT. N.

660022, г. Красноярск, ул. Партизана Железняка, 1

660022, Krasnoyarsk, Partizana Zheleznyaka st., 1

maksi726@mail.ruhttps://orcid.org/0000-0002-7757-6628МедведеваН. Н.MedvedevaN. N.

 д.м.н., проф.

660022, г. Красноярск, ул. Партизана Железняка, 1

doctor of medical sciences, professor

660022, Krasnoyarsk, Partizana Zheleznyaka st., 1

medvenad@mail.ruКрасноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого Минздрава РоссииРоссияProfessor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of Minzdrav of RussiaRussian Federation2023271020234352533Copyright © Афанаскина Л.Н., Деревцова С.Н., Чекишева Т.Н., Медведева Н.Н., 20232023Афанаскина Л.Н., Деревцова С.Н., Чекишева Т.Н., Медведева Н.Н.Afanaskina L.N., Derevtsova S.N., Chekisheva T.N., Medvedeva N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1235

В настоящее время в России и в мире наблюдается увеличение среди населения доли лиц с избыточной массой тела и ожирением, связанным с преобладанием в компонентном составе тела доли жировой массы, что способствует росту числа социально значимых заболеваний. Исходя из этого, повышенное внимание уделяется всестороннему изучению особенностей функционирования всех видов жировой ткани человека, что необходимо для дальнейшего использования этих знаний в борьбе с ожирением. В данной статье приведен обзор данных литературы о строении и свойствах гена PRDM16, особенностях его функционирования в бурой, белой и бежевой жировой ткани. Рассмотрено влияние гена PRDM16 на активацию бурого адипогенеза и формирование бежевых адипоцитов в белой жировой ткани, которые способствуют повышению теплопродукции клеток при помощи несократительного термогенеза и улучшению метаболических параметров организма. Проанализированы сведения о роли белка PRDM16 в лечении ожирения, сахарного диабета 2 типа и других ассоциированных с ним заболеваниях человека. Представлены результаты о способах эффективной активации бурых и бежевых адипоцитов и использовании данных способов в лечении ожирения.

Currently, in Russia and in the world, there is an increase in the proportion of overweight and obese people among the population, which contributes to an increase in the number of socially significant diseases. Obesity is associated with the predominance of the proportion of fat mass in the component composition of the body. Based on this, increased attention is paid to a comprehensive study of the functioning of all types of human adipose tissue, which is necessary for the further use of this knowledge in the fight against obesity. This article provides an overview of the literature data on the structure and properties of the PRDM16 gene, the features of its functioning in brown, white and beige adipose tissue. The influence of the PRDM16 gene on the activation of brown adipogenesis and the formation of beige adipocytes in white adipose tissue, which contribute to increased heat production of cells by means of non-contractile thermogenesis and improvement of metabolic parameters of the body, is considered. Data on the role of PRDM16 protein in the treatment of obesity, type 2 diabetes mellitus and other human diseases associated with it are analyzed. The results on the methods of effective activation of brown and beige adipocytes and the use of these methods in the treatment of obesity are presented.

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The authors declare that there are no conflicts of interest present.