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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20230309</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-1110</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group></article-categories><title-group><article-title>Клинический случай карциномы из клеток Меркеля</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of Merkel cell carcinoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9676-1581</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саранюк</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Saranyuk</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саранюк Роман Владимирович</p><p>305018, г. Курск, просп. Ленинского Комсомола, 2</p></bio><bio xml:lang="en"><p>Roman V. Saranyuk</p><p>305018, Kursk, Leninskogo Komsomola ave., 2</p></bio><email xlink:type="simple">roman.saranuk@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0059-9159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гостева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gosteva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гостева Татьяна Александровна</p><p>305018, г. Курск, просп. Ленинского Комсомола, 2</p></bio><bio xml:lang="en"><p>Tatiana A. Gosteva</p><p>305018, Kursk, Leninskogo Komsomola ave., 2</p></bio><email xlink:type="simple">ya-lisenok-@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цнобиладзе</surname><given-names>Э. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsnobiladze</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цнобиладзе Эдуард Джемалиевич</p><p>305524, Курский р-н, хутор Кислино, ул. Елисеева, 1</p></bio><bio xml:lang="en"><p>Eduard D. Tsnobiladze</p><p>305524, Kursk district, Kislino village, Eliseeva str., 1</p></bio><email xlink:type="simple">Oncologist.eduard@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр медицинских осмотров и профилактики</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Medical Examinations and Prevention</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Курский онкологический научно-клинический центр им. Г.Е. Островерхова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk Cancer Research Clinical Center named after G.E. Ostroverkhov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2023</year></pub-date><volume>43</volume><issue>3</issue><fpage>75</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Саранюк Р.В., Гостева Т.А., Цнобиладзе Э.Д., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Саранюк Р.В., Гостева Т.А., Цнобиладзе Э.Д.</copyright-holder><copyright-holder xml:lang="en">Saranyuk R.V., Gosteva T.A., Tsnobiladze E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/1110">https://sibmed.elpub.ru/jour/article/view/1110</self-uri><abstract><p>Карцинома Меркеля – редкая быстропрогрессирующая агрессивная опухоль кожи с частым метастазированием и высокой смертностью. Заболевание представляет собой мультифакторную патологию, являющуюся результатом взаимодействия эндогенных и экзогенных факторов риска. Своевременное выявление карциномы Меркеля имеет важное значение в плане ведения пациента и прогноза на его выздоровление, так как данное заболевание очень часто ассоциируется с неопластическими процессами не только в коже, но и в других органах. В данной статье представлен клинический случай карциномы Меркеля, рассмотрены вопросы ее этиопатогенеза, дифференциальной диагностики и терапии.</p></abstract><trans-abstract xml:lang="en"><p>Merkel cell carcinoma is a rare, rapidly progressive, aggressive skin tumor with frequent metastasis and high mortality. The disease is a multifactorial pathology resulting from the interaction of endogenous and exogenous risk factors. Timely detection of Merkel cell carcinoma is important in the management and prognosis of the patient, because the disease is often associated with other neoplastic processes not only in the skin but also in other organs. This article presents a clinical case of Merkel cell carcinoma and deals with the issues of its etiopathogenesis, differential diagnostics and therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>карцинома Меркеля</kwd><kwd>полиомавирус</kwd><kwd>УФ-излучение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Merkel carcinoma</kwd><kwd>polyomavirus</kwd><kwd>UV radiation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Harms K.L., Healy M.A., Nghiem P., Sober A.J., Johnson T.M., Bichakjian C.K., Wong S.L. Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system. Ann. Surg. 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