sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20230303sibmed-1104Research ArticleОБЗОРЫREVIEWSБелки сурфактанта SP-A, SP-D и конвенциональные факторы риска хронических неинфекционных заболеваний человекаSP-A and SP-D surfactant proteins and conventional risk factors for chronic non-infectious human diseaseshttps://orcid.org/0000-0003-4601-6203НиколаевК. Ю.NikolaevK. Yu.

Николаев Константин Юрьевич, д.м.н., проф.

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630090, г. Новосибирск, ул. Пирогова, 2

628412, г. Сургут, просп. Ленина, 1

Konstantin Yu. Nikolaev, doctor of medical sciences, professor

630089, Novosibirsk, Borisa Bogatkova str., 175/1

630090, Novosibirsk, Pirogova str., 2

628412, Surgut, Lenina ave., 1

nikolaevky@yandex.ruhttps://orcid.org/0000-0001-8788-685XХарламоваО. С.KharlamovaO. S.

Харламова Ольга Сергеевна, к.м.н.

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Olga S. Kharlamova, candidate of medical sciences

630089, Novosibirsk, Borisa Bogatkova str., 175/1

os@oharlamova.ruКосаревИ. А.KosarevI. A.

Косарев Илья Александрович

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Ilya A. Kosarev

630089, Novosibirsk, Borisa Bogatkova str., 175/1

kia-93@bk.ruДадашоваН. Ф.DadashovaN. F.

Дадашова Назлы Фархад Кызы

628412, г. Сургут, просп. Ленина, 1

Nazly F. Dadashova

628412, Surgut, Lenina ave., 1

nf9555@yandex.ruЛапицкаяЯ. К.LapitskayaYa. K.

Лапицкая Яна Константиновна

630090, г. Новосибирск, ул. Пирогова, 2

Yana K. Lapitskaya

630090, Novosibirsk, Pirogova str., 2

yuno.belka@yandex.ruНИИ терапии и профилактической медицины – филиал ФИЦ Институт цитологии и генетики СО РАН; Новосибирский государственный университет; Сургутский государственный университетРоссияResearch Institute of Internal and Prevention Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics of SB RAS; Novosibirsk State University; Surgut State UniversityRussian FederationНИИ терапии и профилактической медицины – филиал ФИЦ Институт цитологии и генетики СО РАНРоссияResearch Institute of Internal and Prevention Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics of SB RASRussian FederationСургутский государственный университетРоссияSurgut State UniversityRussian FederationНовосибирский государственный университетРоссияNovosibirsk State UniversityRussian Federation2023230620234332838Copyright © Николаев К.Ю., Харламова О.С., Косарев И.А., Дадашова Н.Ф., Лапицкая Я.К., 20232023Николаев К.Ю., Харламова О.С., Косарев И.А., Дадашова Н.Ф., Лапицкая Я.К.Nikolaev K.Y., Kharlamova O.S., Kosarev I.A., Dadashova N.F., Lapitskaya Y.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/1104

Белки сурфактанта SP-A и SP-D, относящиеся к семейству коллагенсодержащих лектинов типа С, используются в качестве диагностических и прогностических маркеров для многих острых и хронических заболеваний бронхолегочной системы. Цель исследования – путем системно-структурного анализа на основании актуальных публикаций из международных баз данных, официальных отчетов ВОЗ оценить влияние конвенциональных факторов риска хронических неинфекционных заболеваний на уровень белков сурфактанта SP-A и SP-D. По результатам проведенного аналитического обзора сделан вывод, что широко распространенная экспрессия SP-A и SP-D задокументирована во множестве исследований, и хотя легкие остаются основным местом синтеза белков сурфактанта, можно ожидать их существенного влияния на иммунный и воспалительный ответ во многих органах и тканях. Авторы отмечают, что известен ряд внелегочных эффектов данных белков. Однако многие механизмы дополнительных клеточных эффектов SP-A и SP-D вне бронхолегочной системы все еще остаются неизученными, что отмечает перспективность дальнейших исследований в данной области.

Surfactant proteins SP-A and SP-D, which belong to the family of collagen-containing type C lectins, are used as diagnostic and prognostic markers for many acute and chronic respiratory diseases. The aim of the study is to assess the impact of conventional risk factors for chronic non-infectious diseases on SP-A and SP-D protein levels by means of systemic and structural analysis on the basis of relevant publications from international databases and official WHO reports. This analytical review concludes that widespread expression of SP-A and SP-D is documented in numerous studies, and, although the lungs remain the main site of synthesis of surfactant proteins, one can expect its significant impact on the immune and inflammatory response in many organs and tissues. The authors note that there are several known extrapulmonary effects of these proteins. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unstudied, which indicates the prospects for further research in this area.

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The authors declare that there are no conflicts of interest present.